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品种反应性 主要应用 宿主 格式 抗体类型 R, H ChIP, WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE553 Replaces 04-218 描述 Anti-CREB-1 Antibody Alternate Names - cAMP-responsive element-binding protein 1
- Cyclic AMP-responsive element-binding protein 1
- CREB-1
背景信息 Cyclic AMP-responsive element-binding protein (CREB) is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2. 产品信息 格式 Affinity Purified 控制 - A431 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect CREB using this rabbit polyclonal antibody, Anti-CREB-1 Antibody validated for use in western blotting & ICC. 主要应用 - Chromatin Immunoprecipitation (ChIP)
- Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected CREB-1 in PC-12 cells.
Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot detected CREB-1 in HEK293T cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the N-terminus of human CREB-1. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the N-terminus of CREB-1. 品种反应性 RatHuman Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Porcine and Equine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004370
基因符号 - CREB1
纯化方法 Affinity purified UniProt编号 - P16220
产品使用声明 质量保证 Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected CREB-1 in 10 µg of A431 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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