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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M ICC, WB, FC M Purified Monoclonal Antibody 描述 产品目录编号 MABF39 描述 Anti-DC-STAMP Antibody, clone 1A2 Alternate Names - IL-4-induced protein
- transmembrane 7 superfamily member 4
- DC-specific transmembrane protein
- IL-Four INDuced
- IL-Four (IL-4) induced
- Dendritic cell-specific transmembrane protein
- Dendritic cells (DC)-specific transmembrane protein
背景信息 Dendritic cell-specific transmembrane protein (DC-STAMP) is a recently described, 470-amino acid, transmembrane protein with a critical role in TNSF11-mediated osteogenesis and giant cell formation. It has also been implicated in a role for inducing tartrate-resistant acid phosphatase expression in osteoclast precursors. DC-STAMP was originally discovered in myeloid dendritic cells as an interleukin-4 (IL-4)-inducible protein consisting of seven transmembrane domains. DC-STAMP is widely expressed with highest levels observed in kidney, liver, lung and lymph node, along with preferential expression in both mature and immature dendritic cells. Lower levels of expression have been observed in bone marrow, leukocytes, pancreas and spleen, and also in freshly isolated B-cells and peripheral blood mononuclear cells (PBMC). 产品信息 格式 Purified 控制 - RAW 264.7 cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-DC-STAMP Antibody, clone 1A2 detects level of DC-STAMP & has been published & validated for use in WB, FC & IC. 主要应用 - Immunocytochemistry
- Western Blotting
- Flow Cytometry
应用说明 Immunocytochemistry Analysis: This antibody has been shown to detect DC-STAMP in IC (Mensah, K.A., et al., 2010).
Flow Cytometry Analysis: This antibody has been shown to detect DC-STAMP in FC (Mensah, K.A., et al., 2010).生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human DC-STAMP at the fourth extracellular domain. 表位 Fourth Extracellular Domain 克隆 1A2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes DC-STAMP at the fourth extracellular domain. 同种型 IgG2aκ 品种反应性 HumanMouse Species Reactivity Note Demonstrated to react with mouse.
Predicted to react with human based on 100% sequence homology.抗体类型 Monoclonal Antibody Entrez基因编号 - NP_110415
Entrez基因汇总 Dendritic cells are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses. The protein encoded by this gene is a transmembrane molecule that is preferentially expressed by dendritic cells. Its expression is down-regulated by ligation of the CD40 molecule. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]. 基因符号 - DCSTAMP
- FIND
- DC-STAMP
纯化方法 Protein G purfied UniProt编号 - Q9H295
UniProt汇总 FUNCTION: Plays an essential role in TNFSF11-mediated osteoclastogenesis. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Potential. Note: Localized to the cell surface. Ref.1
TISSUE SPECIFICITY: Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen and leukocytes. Preferentially expressed by dendritic cells. Detected in both immature and mature dendritic cells. Expressed at lower levels in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.
DEVELOPMENTAL STAGE: Constitutively expressed in dendritic cells from day 3-8 in culture.
INDUCTION: Expression is down-regulated by dexamethasone and up-regulated by IL-4. Down-regulated in CD40 ligand activated dendritic cells.产品使用声明 质量保证 Evaluated by Western Blot in RAW 264.7 cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected DC-STAMP in 10 µg of RAW 264.7 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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