merck millipore,默克密理愽
  • merck millipore,默克密理博,420202,JMJD Histone Demethylase Inhibitor III - Calbiochem

  • merck millipore,默克密理博,420202,JMJD Histone Demethylase Inhibitor III - Calbiochem

    产品名称：JMJD Histone Demethylase Inhibitor III - Calbiochem
    产品型号：420202
    The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,420202,JMJD Histone Demethylase Inhibitor III - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420202,JMJD Histone Demethylase Inhibitor III - Calbiochem

    重要规格表

    经验配方
    C₂₇H₂₉N₃O₆
    描述
    概述 A substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
    产品目录编号 420202
    品牌系列 Calbiochem®
    同义词 (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid, Histone Lysine Demethylase Inhibitor X, JHDM Inhibitor III
    参考
    参考 Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
    产品信息
    形式 Off-white powder
    Hill配方 C₂₇H₂₉N₃O₆
    化学配方 C₂₇H₂₉N₃O₆
    Molar Mass 491.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420202,JMJD Histone Demethylase Inhibitor III - Calbiochem

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