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  • merck millipore,默克密理博,ABD29,Anti-Twist1 (Twist-related protein 1) Antibody

  • merck millipore,默克密理博,ABD29,Anti-Twist1 (Twist-related protein 1) Antibody

    产品名称：Anti-Twist1 (Twist-related protein 1) Antibody
    产品型号：ABD29
    Detect Twist1 (Twist-related protein 1) using this Anti-Twist1 (Twist-related protein 1) Antibody validated for use in IH(P) & IC.

    merck millipore,默克密理博,ABD29,Anti-Twist1 (Twist-related protein 1) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABD29,Anti-Twist1 (Twist-related protein 1) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Eq, H, M, Ca, Po, Rhesus Macaque, ChpICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABD29
    描述 Anti-Twist1 (Twist-related protein 1) Antibody
    Alternate Names
    • H-twist
    • Twist-related protein 1
    • Class A basic helix-loop-helix protein 38
    • bHLHa38
    背景信息 Twist1 is the basic helix-loop-helix transcription factor that regulates embryonic progenitor and transformed tumor cell proliferation, migration and differentiation and is also important in limb development. It has been shown that twist1 expression is high in patients suffering from rheumatic inflammatory disorders with chronically activated T helper lymphocytes and may be used as a biomarker for chronic t-cell activation. Mutations in twist1 are often associated with craniofacial and limb abnormalities in humans with Saethre-Chotzen syndrome. Twist1 dimer affinity can modify the DNA binding affinity. Twist1 has also been implicated as a promoter of tumor growth, invasion and anti-cancer-drug resistance.
    产品信息
    格式 Affinity Purified
    控制
    • Ductal breast fibroadenoma and stratified squamous epithelium and cartilage of human trachea tissues
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Twist1 (Twist-related protein 1) using this Anti-Twist1 (Twist-related protein 1) Antibody validated for use in IH(P) & IC.
    主要应用
    • Immunocytochemistry
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Twist1 in NIH/3T3, A431, and HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Twist1 near the N-terminus.
    表位 Near N-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Twist1 near the N-terminus.
    品种反应性 HorseHumanMouseCaninePigRhesus MacaqueChimpanzee
    Species Reactivity Note Demonstrated to react with Human and Mouse. Predicted to react with Pig, Rhesus Monkey, Chimpanzee, Equine, Gorilla, and Canine based on 100% sequence homology. Other homologies: Rat (92% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000465
    Entrez基因汇总 Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq].
    基因符号
    • TWIST
    • TWIST1
    • BHLHA38
    纯化方法 Affinity purified
    UniProt编号
    • Q15672
    UniProt汇总 FUNCTION: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.

    SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer or heterodimer with E proteins such as TCF3. ID1 binds preferentially to TCF3 but does not interact efficiently with TWIST1 so ID1 levels control the amount of TCF3 available to dimerize with TWIST1 and thus determine the type of dimer formed (By similarity).

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICTY: Subset of mesodermal cells.

    INVOLVEMENT IN DISEASE: Defects in TWIST1 are a cause of Saethre-Chotzen syndrome (SCS) [MIM:101400]; also known as acrocephalosyndactyly type 3 (ACS3). SCS is a craniosynostosis syndrome characterized by coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

    Defects in TWIST1 are the cause of Robinow-Sorauf syndrome (RSS) [MIM:180750]; also known as craniosynostosis-bifid hallux syndrome. RSS is an autosomal dominant defect characterized by minor skull and limb anomalies which is very similar to Saethre-Chotzen syndrome.

    Defects in TWIST1 are the cause of craniosynostosis type 1 (CRS1) [MIM:123100]. Craniosynostosis consists of premature fusion of one or more cranial sutures, resulting in an abnormal head shape.

    SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in ductal breast fibroadenoma and stratified squamous epithelium and cartilage of human trachea tissues.

    Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Twist1 in ductal breast fibroadenoma and stratified squamous epithelium and cartilage of human trachea tissues.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABD29,Anti-Twist1 (Twist-related protein 1) Antibody

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