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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC97 描述 Anti-Birc7/LIVIN Antibody Alternate Names - RING finger protein 50
- Baculoviral IAP repeat-containing protein 7
- Kidney inhibitor of apoptosis protein
- KIAP
- Livin
- Melanoma inhibitor of apoptosis protein
- ML-IAP
背景信息 Livin, also known as “baculoviral IAP repeat-containing protein 7” (Birc7) and "KIAP," is a member of the IAP (inhibitors of apoptosis) family of proteins characterized by highly conserved baculoviral IAP repeats (BIR). In addition, Livin contains one RING-type zinc finger domain. Livin has been detected in the heart, placental, lung, lymph node, ovary, spleen, and in various types of solid tumors. It may suppress apoptosis induced by TNF, viral infection, drugs, and growth factor withdrawal, by inhibiting caspase activity (caspase 3, 7, and 9) and activating a MAPK/JUN pathway. Paradoxically, Livin may also function as a pro-apoptic factor in a truncated form (tLivin) that is cleaved by caspase 3 from the full-length protein. The pro-apoptotic effects of Livin may depend on its RING domain. Livin may play a role in non-Hodgkin lymphoma. 产品信息 格式 Affinity Purified 控制 - Human spleen tissue lysate
演示 Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Birc7/LIVIN detects levels of Birc7/LIVIN proteins & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the BIR repeat region of human Birc7/LIVIN. 表位 BIR repeat region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the BIR repeat region of Birc7/LIVIN. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Rat, Mouse, and Bovine (93% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_647478
基因符号 - RNF50
- BIRC7
- KIAP
- LIVIN
- MLIAP
纯化方法 Affinity purified UniProt编号 - Q96CA5
产品使用声明 质量保证 Evaluated by Western Blot in human spleen tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Birc7/LIVIN in 10 µg of human spleen tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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