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品种反应性 主要应用 宿主 抗体类型 H ELISA, WB, IHC Rb Polyclonal Antibody 描述 产品目录编号 AB15514 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Neuroligin 3 Antibody 背景信息 Neuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. 产品信息 演示 Liquid in PBS with 0.1% BSA and 0.05% sodium azide 应用 应用 This Anti-Neuroligin 3 Antibody is validated for use in WB, IH, ELISA for the detection of Neuroligin 3. 主要应用 - ELISA
- Western Blotting
- Immunohistochemistry
应用说明 Western blot: 1-10 μg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 μg/mL
ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide near the C-terminus of human Neuroligin 3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Neuroligin 3 (NLGN3) 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_018977.2
Entrez基因汇总 This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined. 基因符号 - KIAA1480
- NLGN3
- HNL3
- NL3
- AUTSX1
- ASPGX1
UniProt编号 - Q9NZ94
UniProt汇总 FUNCTION: SwissProt: Q9NZ94 # Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia- glia or glia-neuron interactions in the developing peripheral nervous system.
SIZE: 848 amino acids; 93895 Da
SUBUNIT: Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta (By similarity). Probably interacts through its C- terminus with DLG4/PSD-95 third PDZ domain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
DISEASE: SwissProt: Q9NZ94 # Defects in NLGN3 may be the cause of susceptibility to X- linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. & Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.
SIMILARITY: SwissProt: Q9NZ94 ## Belongs to the type-B carboxylesterase/lipase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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