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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC839 描述 Anti-ATR Antibody Alternate Names - Tumor endothelial marker 8
- Anthrax toxin receptor 1
背景信息 The Anthrax toxin receptor 1 (also known as Tumor endothelial marker 8, ANTXR1 and ATR) was initially discovered as the tumor endothelial marker (TEM8). This protein, which exists in three isoforms (33, 37, 41, and 63 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-ATR Antibody is a highly specific rabbit polyclonal antibody, that targets ATR & has been tested in western blotting, IHC & ICC. 主要应用 - Immunocytochemistry
- Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: 2 μg/mL from a representative lot detected ATR in human brain tissue.
Immunocytochemistry Analysis: 10 μg/mL from a representative lot detected ATR in human brain cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to 13 amino acids near the center region of human ATR. 表位 Center region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - TEM8
- ANTXR1
- ATR
纯化方法 Purified by ion-exchange chromatography UniProt编号 - Q9H6X2
产品使用声明 质量保证 Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected ATR in HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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