merck millipore,默克密理愽
  • merck millipore,默克密理博,440165,LXRα/β Agonist - CAS 264206-85-1 - Calbiochem

  • merck millipore,默克密理博,440165,LXRα/β Agonist - CAS 264206-85-1 - Calbiochem

    产品名称：LXRα/β Agonist - CAS 264206-85-1 - Calbiochem
    产品型号：440165
    The LXRα/β Agonist, also referenced under CAS 264206-85-1, controls the biological activity of LXRα/β. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,440165,LXRα/β Agonist - CAS 264206-85-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,440165,LXRα/β Agonist - CAS 264206-85-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₂₀N₂O₃264206-85-1
    描述
    概述 A cell-permeable maleimide analog that acts as a potent and specific liver X receptor (LXR) dual agonist (EC50 = 50 nM and 40 nM for the recruitment of SRC1 to LXRα and LXRβ, respectively). Displays >50-fold selectivity for LXR over a panel of nuclear receptors, including FXR, PPARα/γ/δ, PXR, AR, ERα/β, GR, and PR. Upregulates ABCA1-dependent transcriptional activity (EC50 = 80 nM) and inhibits LPS-stimulated secretion of the proinflammatory cytokine, IL-6, in THP-1 cells.
    产品目录编号 440165
    品牌系列 Calbiochem®
    同义词 3-((4-Methoxyphenyl)amino)-4-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione
    参考
    参考 Jaye, M.C., et al. 2005. J. Med. Chem. 48, 5419.
    产品信息
    CAS号 264206-85-1
    具有ATP竞争性 N
    形式 Orange solid
    Hill配方 C₂₄H₂₀N₂O₃
    化学配方 C₂₄H₂₀N₂O₃
    Molar Mass 384.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 A potent and specific liver X receptor (LXR) dual agonist
    主靶IC50 EC50 = 50 nM and 40 nM for the recruitment of SRC1 to LXRα and LXRβ, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,440165,LXRα/β Agonist - CAS 264206-85-1 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,MAB1207,Anti-Platelet IIb-IIIa Antibody, clone 290AS-10. a.k.a. HuPl-m1
下一件merck millipore产品：merck millipore,默克密理博,69048,T7•Tag Antibody HRP Conjugate


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