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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC57 描述 Anti-IDH2 Antibody Alternate Names - Oxalosuccinate decarboxylase
- Isocitrate dehydrogenase [NADP], mitochondrial
- IDH
- ICD-M
- IDP
- NADP(+)-specific ICDH
背景信息 Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) is a 452 amino acid enyzme belonging to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains mitochondrial glutathione levels. Studies suggest that IDH2 plays a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. 产品信息 格式 Affinity Purified 控制 - Mouse heart tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect the IDH2 protein using this Anti-IDH2 validated for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A previous lot of this antibody detected IDH2 in human MOLT-4 cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human IDH2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human and Mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002159
Entrez基因汇总 Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008]. 基因符号 - IDH2
纯化方法 Affinity Purified UniProt编号 - P48735
UniProt汇总 FUNCTION: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
CATALYTIC ACTIVITY: Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
COFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).
SUBUNIT STRUCTURE: Homodimer.
SUBCELLULAR LOCATION: Mitochondrion.
INVOLVEMENT IN DISEASE: Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2) [MIM:613657]. D2HGA2 is a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.
SEQUENCE SIMILARITIES: Belongs to the isocitrate and isopropylmalate dehydrogenases family.产品使用声明 质量保证 Evaluated by Western Blot in mouse heart tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected IDH2 in 10 µg of mouse heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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