• merck millipore,默克密理博,557440,Ru360 - Calbiochem
  • merck millipore,默克密理博,557440,Ru360 - Calbiochem

    产品名称:Ru360 - Calbiochem
    产品型号:557440
    A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM).

    merck millipore,默克密理博,557440,Ru360 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,557440,Ru360 - Calbiochem

    重要规格表

    经验配方
    C₂H₂₆Cl₃N₈O₅Ru₂
    描述
    概述 A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels.
    Note: 1 set = 10 x 100 µg.
    产品目录编号 557440
    品牌系列 Calbiochem®
    同义词 (μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
    参考
    参考 Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
    Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
    Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
    Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
    Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
    Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
    产品信息
    具有ATP竞争性 N
    形式 Reddish brown solid
    Hill配方 C₂H₂₆Cl₃N₈O₅Ru₂
    化学配方 C₂H₂₆Cl₃N₈O₅Ru₂
    Molar Mass 550.8
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 Ca2+ uptake into mitochondria in vitro
    主靶IC50 184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
    纯度 ≥97% by capillary electrophoresis
    理化信息
    细胞可渗透 Y
    溶解度 deoxygenated H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Unstable in solution; reconstitute just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,557440,Ru360 - Calbiochem

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