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经验配方 C₂H₂₆Cl₃N₈O₅Ru₂ 描述 概述 A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels. Note: 1 set = 10 x 100 µg. 产品目录编号 557440 品牌系列 Calbiochem®
同义词 (μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃ 参考 参考 Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
Ying, W.-L., et al. 1991. Biochemistry 30, 4949.产品信息 具有ATP竞争性 N 形式 Reddish brown solid Hill配方 C₂H₂₆Cl₃N₈O₅Ru₂ 化学配方 C₂H₂₆Cl₃N₈O₅Ru₂ Molar Mass 550.8 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 Ca2+ uptake into mitochondria in vitro 主靶IC50 184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria 纯度 ≥97% by capillary electrophoresis 理化信息 细胞可渗透 Y 溶解度 deoxygenated H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Unstable in solution; reconstitute just prior to use. 包装信息 惰性气体下包装 Packaged under inert gas
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