merck millipore,默克密理博,ABC392,Anti-CYP17A1 Antibody

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merck millipore,默克密理博,ABC392,Anti-CYP17A1 Antibody
产品名称：Anti-CYP17A1 Antibody
产品型号：ABC392
Anti-CYP17A1 Antibody is a highly specific rabbit polyclonal antibody, that targets Cytochrome P450 & has been tested in western blotting, IHC & Immunofluorescence.

merck millipore,默克密理博,ABC392,Anti-CYP17A1 Antibody

产品介绍

merck millipore,默克密理博,ABC392,Anti-CYP17A1 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABC392
描述	Anti-CYP17A1 Antibody
Alternate Names	Steroid 17-alpha-monooxygenase Steroid 17-alpha-hydroxylase/17,20 lyase 17-alpha-hydroxyprogesterone aldolase CYPXVII CYP17A1 Cytochrome P450-C17 Cytochrome P450c17
背景信息	Cytochrome P450 17A1 (CYP17A1) or alternatively Cytochrome P450-C17, CYPXVII, or Steroid 17-alpha-hydroxylase/17, lyase-steroid 17-alpha-monoxygenase is an enzyme encoded by the human gene CYP17A1/CYP17/S17AH that is the enzyme that plays a critical role in the breakdown of cholesterol into various important hormones such as glucocorticoids and androgens (sex hormones). Specifically, CYP17A1 converts pregnenolone and progesterone into their 17 hydoxy forms which are then converted to mineralocorticoids and glucocorticoids. CYP17A1 can also convert these 17 hydroxy forms into DHEA and androstenedione which become male sex hormones and androgens. In cancer, because prostate cancers often proliferate in response to androgens, CYP17A1 is now also a focus of much drug and inhibitor research as a cancer preventative. Interestingly CYP17A1 polymorphisms are also associated with various forms of lymphoma and other cancers, as well as a number of mineral, salt and sex hormone effected diseases.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.

应用
应用	Anti-CYP17A1 Antibody is a highly specific rabbit polyclonal antibody, that targets Cytochrome P450 & has been tested in western blotting, IHC & Immunofluorescence.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected CYP17A1 in human prostate cancer tissue. Immunofluorescence Analysis: A 1:50 dilution from a representative lot detected CYP17A1 in HepG2 cells.

生物信息
免疫原品种	GST-tagged fusion protein corresponding to human CYP17A1.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	S17AH CYP17A1 CYP17
纯化方法	Antigen Affinity purified
UniProt编号	P05093

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: A 1:300 dilution of this antibody detected CYP17A1 in HeLa cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.