merck millipore,默克密理博,328007,ERK Inhibitor II, FR180204 - CAS 865362-74-9

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

merck millipore,默克密理博,328007,ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem

经验配方	CAS号
C₁₈H₁₃N₇	865362-74-9

描述
概述	A cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC₅₀ = 510 nM and 330 nM; K_i = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC₅₀ = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC₅₀ = 3.1 µM). ERK Inhibitor II, Negative Control is also available (Cat. No. 328008). Also available as a 10 mM solution in DMSO (Cat. No. 328010).
产品目录编号	328007
品牌系列	Calbiochem®
同义词	5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

参考
参考	Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.

生物信息
主靶	ERK1 and ERK2
主靶IC₅₀	510 nM and 330 nM
主靶K_i	310 nM and 140 nM, against ERK1 and ERK2, respectively
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,328007,ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech