merck millipore,默克密理博,MABE222,Anti-JMJD2A Antibody, clone 8B7.1, rabbit monoclonal

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	MABE222
描述	Anti-JMJD2A Antibody, clone 8B7.1, rabbit monoclonal
Alternate Names	Jumonji domain-containing protein 2A JMJD Lysine-specific demethylase 4A JmjC domain-containing histone demethylation protein 3A
背景信息	Jumonji domain-containing protein 2A (JMJD2A), or KDM4A, is a ubiquitously expressed demethylase enzyme, which belongs to the JMJD2 family. Like other members of this family, JMJD2A contains multiple domains: two Tudor domains, two PHD-type zinc fingers, one JmjC domain, and one JmjN domain. Little is known about the function of most of these domains; however, they are believed to be involved in transcriptional regulation. JMJD2A functions as a histone demethylase with specific activity against trimethylated Histone H3 Lysine residues Lys-9 and Lys-36. It has no effect on any other lysine residues, or on mono- and dimethylated Lys-9 and Lys-36. The demethylation of these residues induces the production of succinate and formaldehyde. Studies have shown that JMJD2A recruits NCOR1 and histone deacetylases, causing the respective transcriptional repression of E2Fand ASCL2 responsive promoters.

产品信息
格式	Purified
控制	U2OS nuclear extract
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Anti-JMJD2A Antibody, clone 8B7.1 is validated for use in Western Blotting, IHC for the detection of JMJD2A.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected JMJD2A in human colorectal adenocarcinoma cells.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human JMJD2A.
克隆	8B7.1
宿主	Rabbit
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_055478
基因符号	KIAA0677 KDM4A JHDM3A JMJD2
纯化方法	Protein G purified
UniProt编号	O75164

产品使用声明
质量保证	Evaluated by Western Blot in U2OS nuclear extract. Western Blot Analysis: A 1:1,000 dilution of this antibody detected JMJD2A in 10 µg of U2OS nuclear extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,MABE222,Anti-JMJD2A Antibody, clone 8B7.1, rabbit monoclonal

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