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品种反应性 主要应用 宿主 格式 抗体类型 H IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC330 描述 Anti-ACVR1 Antibody Alternate Names - ALK-2
- ACVR1
- Activin A receptor type IA
- Activin receptor-like kinase 2
- Activin receptor type 1A precursor
- Serine/threonine-protein kinase receptor R1
- SKR1
- TGF-B superfamily receptor type I
- TSR-I
- ACTR-IA
- ACVRLK2
- ALK2
背景信息 Activin receptor type-1 (ACVR1) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. Activins are growth and differentiation factors that belong to the transforming growth factor-beta (TGF-beta) superfamily. ACVR1 plays a role in ligand binding and forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. The process of forming this receptor complex involves the phosphorylation of Type II receptors; the activation of Type I receptors; the autophosphorylation of Type I receptors, which then bind and activate SMAD transcriptional regulators. ACVR1 is expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Furthermore, ACVR1 is shown to interact with FKBP1A and FCHO1. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) - a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Additionally, ACVR1 may play a role in the left-right pattern formation during embryogenesis. 产品信息 格式 Affinity Purified 控制 - Human prostate carcinoma and breast cancer tissue
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-ACVR1 Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in IHC. 主要应用 - Immunohistochemistry
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human ACVR1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the N-terminus of ACVR1. 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - ACVR1
纯化方法 Antigen Affinity purified UniProt编号 - Q04771
产品使用声明 质量保证 Evaluated by Immunohistochemistry in human prostate carcinoma and breast cancer tissue.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected ACVR1 in human prostate carcinoma and breast cancer tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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