merck millipore,默克密理愽
  • merck millipore,默克密理博,555555,Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem

  • merck millipore,默克密理博,555555,Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem

    产品名称：Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem
    产品型号：555555
    The Rho Kinase Inhibitor V, also referenced under CAS 1072906-02-5, controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>

    merck millipore,默克密理博,555555,Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,555555,Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₅N₃O₃1072906-02-5
    描述
    概述 A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC50 = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC50 = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC50 = 0.186, 1.19, and 1.41 µM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 µM = 87/40/1/20, respectively) only at much higher concentrations.
    Feng, Y., et al. 2008. J. Med. Chem. 51, 6642.
    产品目录编号 555555
    品牌系列 Calbiochem®
    同义词 N-(4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
    产品信息
    CAS号 1072906-02-5
    形式 Light beige solid
    Hill配方 C₁₈H₁₅N₃O₃
    化学配方 C₁₈H₁₅N₃O₃
    Molar Mass 321.3
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,555555,Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem

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