merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1520,Anti-phospho-Grb10 (Ser501/Ser503) Antibody

  • merck millipore,默克密理博,07-1520,Anti-phospho-Grb10 (Ser501/Ser503) Antibody

    产品名称：Anti-phospho-Grb10 (Ser501/Ser503) Antibody
    产品型号：07-1520
    Anti-phospho-Grb10 (Ser501/Ser503) Antibody detects level of phospho-Grb10 (Ser501/Ser503) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-1520,Anti-phospho-Grb10 (Ser501/Ser503) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1520,Anti-phospho-Grb10 (Ser501/Ser503) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Pm, M, H, Po, Rhesus Macaque, EqWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1520
    描述 Anti-phospho-Grb10 (Ser501/Ser503) Antibody
    Alternate Names
    • insulin receptor-binding protein Grb-IR
    • growth factor receptor-bound protein 10
    • OTTHUMP00000197988
    • OTTHUMP00000197989
    • OTTHUMP00000197990
    • OTTHUMP00000197991
    • OTTHUMP00000197992
    • OTTHUMP00000197993
    • OTTHUMP00000197994
    • GRB10 adapter protein
    • GRB10 adaptor protein
    • maternally expressed gene 1
    背景信息 Growth factor receptor-bound protein 10 (Grb10) belongs to a small family of structurally related multi-domain adaptor proteins, which are known to be involved with a diverse array of functions, including cellular growth, metabolism, apoptosis, and cell migration. Grb10 is widely, but not uniformly, expressed in mammalian tissues, and there are various known isoforms of Grb10. It is shown to bind to and positively or negatively mediate signals from a number of activated receptor tyrosine kinases, including the insulin (INSR) and the insulin-like growth factor (IGF1R and IGF2R) receptors, in addition to a variety of growth factor receptors and intracellular molecules, in a context-dependent manner. In one study, mTORC1-mediated Grb10 phosphorylation is demonstrated to lead to feedback inhibition of the phosphatidylinositol-3-kinase (PI3K) and the extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways in HEK 293T cells, in vivo. However, many aspects of the Grb10 adapter function remain unclear. Further research is still required to elucidate and validate the interactions and effects of GRB10 with various cellular targets.
    产品信息
    格式 Affinity Purified
    控制
    • Insulin untreated and treated mouse embryonic fibroblast cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho-Grb10 (Ser501/Ser503) Antibody detects level of phospho-Grb10 (Ser501/Ser503) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Grb10 phosphorylated at Ser501/Ser503.
    表位 Phosphorylated Ser501/Ser503.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Grb10 phosphorylated at Ser501/Ser503.
    品种反应性 PrimateMouseHumanPigRhesus MacaqueHorse
    Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human, Porcine, Rhesus Macaque, Equine, and Primate based on 100% sequence homology. Other homologies: Rat (91% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005302
    Entrez基因汇总 The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
    基因符号
    • KIAA0207
    • GRB10
    • GRBIR
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • Q13322
    UniProt汇总 FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

    SUBUNIT STRUCTURE: Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain By similarity. Poorly binds to the EGFR By similarity. Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15 By similarity. When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6 By similarity. Binds to activated NRAS.

    SUBCELLULAR LOCATION: Cytoplasm.
    产品使用声明
    质量保证 Evaluated by Western Blot in insulin untreated and treated mouse embryonic fibroblast cell lysates.

    Western Blot Analysis: 1 µg/mL of this antibody detected Grb10 in 10 µg of insulin untreated and treated mouse embryonic fibroblast cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-1520,Anti-phospho-Grb10 (Ser501/Ser503) Antibody

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