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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3637 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-DEDAF Antibody 产品信息 格式 Purified 演示 Purified IgG by immunoaffinity chromatography. Liquid in PBS containing 0.02% sodium azide. 应用 应用 This Anti-DEDAF Antibody is validated for use in WB for the detection of DEDAF. 主要应用 - Western Blotting
应用说明 Western blot: 0.5-1 μg/mL.
A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rabbit anti-DEDAF polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 215 to 228 of human-DEDAF. This sequence is identical to the mouse sequence. 宿主 Rabbit 特异性 Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. DEDAF (DED Associated Factor) is expressed in multiple tissues and cell lines. DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/Caspase-8 complexes at the cell membrane. DEDAF also interacts with DEDD (DED-containing DNA binding) protein in the nucleus, which indicates its involvement in the regulation of both cytoplasmic and nuclear events of apoptosis. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_012234.4
基因符号 - APAP-1
- RYBP
- DEDAF
- YEAF1
- AAP1
UniProt编号 - Q8N488
UniProt汇总 FUNCTION: SwissProt: Q8N488 # May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
SIZE: 228 amino acids; 24822 Da
SUBUNIT: Interacts with CBX2, YAF2, RING1 and RNF2 (By similarity). Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and E4TF1B. Together with E4TF1B and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Primarily found in the nucleus.
TISSUE SPECIFICITY: Widely expressed with highest levels in lymphoid tissues and placenta.
SIMILARITY: SwissProt: Q8N488 ## Contains 1 RanBP2-type zinc finger.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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