merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10140,Anti-Drebrin A/E Antibody

  • merck millipore,默克密理博,AB10140,Anti-Drebrin A/E Antibody

    产品名称：Anti-Drebrin A/E Antibody
    产品型号：AB10140
    Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.

    merck millipore,默克密理博,AB10140,Anti-Drebrin A/E Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10140,Anti-Drebrin A/E Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, M, RICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB10140
    描述 Anti-Drebrin A/E Antibody
    Alternate Names
    • drebrin E2
    • Developmentally-regulated brain protein
    • drebrin 1
    • drebrin E
    背景信息 The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast
    产品信息
    格式 Affinity Purified
    控制
    • Embryonic rat brain (day 16) tissue lysate.
    演示 Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.
    应用
    应用 Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.
    生物信息
    免疫原品种 KLH conjugated synthetic linear peptide.
    表位 Internal Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Cat. # AB10140 detects the internal domain of Drebrin A/E.
    品种反应性 HumanMouseRat
    Species Reactivity Note Mouse and Rat. May react with human based on sequence homology. Reactivity with other species has not been determined.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004395.3
    Entrez基因汇总 The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq]
    基因符号
    • drebrin-1
    • D0S117E
    • DKFZp434D064
    纯化方法 Antigen affinity purified
    UniProt编号
    • Q07266
    UniProt汇总 FUNCTION: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.

    SUBUNIT STRUCTURE: Binds F-actin.

    SUBCELLULAR LOCATION: Cytoplasm.

    TISSUE SPECIFICITY: Brain neurons.

    MISCELLANEOUS: Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related. Adult rat brain expresses only drebrin A while drebrin E1 or E2 is observed in immature animals.

    SEQUENCE SIMILARITIES: Contains 1 ADF-H domain.
    产品使用声明
    质量保证 Western Blot:
    A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB10140,Anti-Drebrin A/E Antibody

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