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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB9918 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Glucocorticoid Receptor Antibody Alternate Names - GR Nuclear receptor subfamily 3 group C member 1
背景信息 The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. 产品信息 格式 Serum 演示 Raw rabbit serum with 0.05% sodium azide. 应用 应用 Anti-Glucocorticoid Receptor Antibody is an antibody against Glucocorticoid Receptor for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot: 1:5000 生物信息 免疫原品种 Recombinant human glucocorticoid receptor 表位 AA D2 – P400 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000167
Entrez基因汇总 The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. 基因符号 - GR
- GRL
- GCCR
- GCR
UniProt编号 - P04150
UniProt汇总 FUNCTION: SwissProt: P04150 # Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
SIZE: 777 amino acids; 85659 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding.
SIMILARITY: SwissProt: P04150 # Belongs to the nuclear hormone receptor family. NR3 subfamily.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to 12 months from date of receipt. 包装信息 数量 50 µL
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