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品种反应性 主要应用 宿主 格式 抗体类型 H IHC Sh Serum Polyclonal Antibody 描述 产品目录编号 AB9704 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-LRRK2 Antibody Alternate Names - Dardarin, Leucine-rich repeat kinase 2
- Dardarin
产品信息 格式 Serum 演示 Sheep serum. Lyophilized. Reconstitute with 100 μL of sterile distilled water. 应用 应用 Detect LRRK2 using this ANTI-LRRK2 Antibody validated for use in IH. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry: 1:1,000-1:8,000. The antibody works well on both cryosections and paraffin embedded tissues.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from human LRRK2. 宿主 Sheep 特异性 Recognizes LRRK2 (leucine-rich repeat kinase 2, Dardarin) 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_198578.2
Entrez基因汇总 This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. 基因符号 - EC 2.7.11.1
- LRRK2
- AURA17
- RIPK7
- ROCO2
- dardarin
- FLJ45829
- PARK8
- DKFZp434H2111
- Dardarin
UniProt编号 - Q5S007
UniProt汇总 FUNCTION: SwissProt: Q5S007 # Probable protein kinase whose role is not yet known. May play a role in the phosphorylation of proteins central to Parkinson disease. May also have GTPase activity.
SIZE: 2527 amino acids; 286058 Da
SUBUNIT: Interacts with PARK2.
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane.
TISSUE SPECIFICITY: Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
DISEASE: SwissProt: Q5S007 # Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8) [MIM:607060, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late- onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.
SIMILARITY: SwissProt: Q5S007 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 16 LRR (leucine-rich) repeats. & Contains 1 Miro domain. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ACS grade or better) can be added (1:1) for additional stability. 包装信息 数量 100 µL
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