merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE145,Anti-Runx3 Antibody, clone R3-5G4

  • merck millipore,默克密理博,MABE145,Anti-Runx3 Antibody, clone R3-5G4

    产品名称：Anti-Runx3 Antibody, clone R3-5G4
    产品型号：MABE145
    Use Anti-Runx3 Antibody, clone R3-5G4 (mouse monoclonal antibody) validated in WB, IP to detect Runx3 also known as Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, PEA2-alpha C, More>>

    merck millipore,默克密理博,MABE145,Anti-Runx3 Antibody, clone R3-5G4

  • 产品介绍
  • merck millipore,默克密理博,MABE145,Anti-Runx3 Antibody, clone R3-5G4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE145
    描述 Anti-Runx3 Antibody, clone R3-5G4
    Alternate Names
    • SL3/AKV core-binding factor alpha C subunit
    • Runt-related transcription factor 3
    • Acute myeloid leukemia 2 protein
    • Core-binding factor subunit alpha-3
    • CBF-alpha-3
    • Oncogene AML-2
    • Polyomavirus enhancer-binding protein 2 alpha C subunit
    • PEA2-alpha C
    • PEBP2-alpha C
    • SL3-3 enhancer factor 1 alpha C subunit
    背景信息 Runx3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.
    产品信息
    格式 Purified
    控制
    • Daudi cell lysate.
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-Runx3 Antibody, clone R3-5G4 (mouse monoclonal antibody) validated in WB, IP to detect Runx3 also known as Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, PEA2-alpha C, PEBP2-alpha C.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Runx3 in HCT116, SW620, and SW480 nuclear extracts. (Ito, K., et al. (2008). Cancer Cell. 14(3):226-237.)
    生物信息
    免疫原品种 Recombinant protein corresponding to human Runx3.
    克隆 R3-5G4
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001026850
    基因符号
    • PEBP2A3
    • RUNX3
    • AML2
    • CBFA3
    纯化方法 Protein G purified
    UniProt编号
    • Q13761
    UniProt汇总 FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

    SUBUNIT STRUCTURE Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK.

    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: The tyrosine phosphorylated form localizes to the cytoplasm.
    产品使用声明
    质量保证 Evaluated by Western Blot in Daudi cell lysate.

    Western Blot Analysis: 0.25 mg/mL of this antibody detected Runx3 in 10 µg Daudi cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABE145,Anti-Runx3 Antibody, clone R3-5G4

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