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merck millipore,默克密理博,445874,mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem
产品名称：mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem
产品型号：445874
The mGluR5 Antagonist, MTEP, also referenced under CAS 329205-68-7, controls the biological activity of mGluR5. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,445874,mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₁H₈N₂S 329205-68-7 描述 概述 A brain-permeable (thiazole-pyridine)alkyne compound that acts as a potent, selective and non-competitive mGluR5 (metabotropic glutamate receptor subtype-5) antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM) with in vivo anxiolytic activity in a rodent model (ED50 = 1 mg/kg, ip and 7 mg/kg, po). Devoid of any side effects seen with MPEP and benzodiazepines. Reported to weakly affect the activities of other enzymes and receptors tested (IC50 = 30 µM for MAO-A, > 100 µM for mGlu1R, 2R & 7R, and > 300 µM for NR2BR). 产品目录编号 445874 品牌系列 Calbiochem®
同义词 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine 参考 参考 Bradbury, M.J., et al. 2005. J. Pharmacol. Exp. Ther. 313, 395.
Busse, C.S., et al. 2004. Neuropsychopharmacology 29, 1971.
Roppe, J.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3993.
Klodzinska, A., et al. 2004. Neuropharmacology 47, 342.
Cosford, N.D.P., et al. 2003. J. Med. Chem. 46, 204.
Brodkin, J., et al. 2002. Eur. J. Neurosci. 16, 2241.产品信息 CAS号 329205-68-7 具有ATP竞争性 N 形式 Yellowish-white solid Hill配方 C₁₁H₈N₂S 化学配方 C₁₁H₈N₂S Molar Mass 200.3 可逆 N 结构配方图像 生物信息 主靶 mGluR5 主靶IC50 5 nM in Ca2+-flux assay 主靶Ki 16 nM for mGluR5 (metabotropic glutamate receptor subtype-5) 纯度 ≥98% by NMR 理化信息 细胞可渗透 Y 溶解度 DMSO or MeOH 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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