merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF33,Anti-MHC class II (I-A/I-E) Antibody, clone M5/114

  • merck millipore,默克密理博,MABF33,Anti-MHC class II (I-A/I-E) Antibody, clone M5/114

    产品名称：Anti-MHC class II (I-A/I-E) Antibody, clone M5/114
    产品型号：MABF33
    Detect MHC class II (I-A/I-E) using this Anti-MHC class II (I-A/I-E) Antibody, clone M5/114 validated for use in WB, FC, IH.

    merck millipore,默克密理博,MABF33,Anti-MHC class II (I-A/I-E) Antibody, clone M5/114

  • 产品介绍
  • merck millipore,默克密理博,MABF33,Anti-MHC class II (I-A/I-E) Antibody, clone M5/114

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, FC, IHCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF33
    描述 Anti-MHC class II (I-A/I-E) Antibody, clone M5/114
    Alternate Names
    • CD74 antigen
    • CD74 molecule, major histocompatibility complex, class II invariant chain
    • Ia-associated invariant chain
    • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
    • gamma chain of class II antigens
    • Ia antigen-associated invariant chain
    • MHC HLA-DR gamma chain
    • HLA class II histocompatibility antigen gamma chain
    • HLA-DR antigens-associated invariant chain
    • HLA-DR-gamma
    背景信息 MHC class II-associated invariant chain (I-A/I-E), also known as Ia antigen-associated invariant chain, are single-pass type II membrane glycoproteins containing a single thyroglobulin type-I domain. They are critical components in the processing of MHC class II antigen through forming a stabilizing complex following the alpha/beta heterodimer synthesis, and orchestrating complex trafficking away from the ER compartments in which class II peptide loading occurs.
    产品信息
    格式 Purified
    控制
    • Mouse spleen tissue lysate
    演示 Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect MHC class II (I-A/I-E) using this Anti-MHC class II (I-A/I-E) Antibody, clone M5/114 validated for use in WB, FC, IH.
    主要应用
    • Western Blotting
    • Flow Cytometry
    • Immunohistochemistry
    应用说明 Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC on spleen cells. (Bhattacharya, A., et al. (1981). The Journal of immunology. 127(6):2488-2496.)

    Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH on thymus tissue. (de Bont, E., et al. (1999). Int. Immunol. 11(8):1295-1306.)
    生物信息
    免疫原品种 B6 Anti-BNL4Φ lymphocytes
    克隆 M5/114
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2bκ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001036070
    基因符号
    • Ii
    • Ia-GAMMA
    • DHLAG
    • CD74
    • p33
    • HLADG
    • ii
    纯化方法 Protein G Purified
    UniProt编号
    • P04441
    UniProt汇总 FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

    SUBUNIT STRUCTURE: Nonamer composed of three alpha/beta/gamma heterotrimers (By similarity).

    SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).

    SEQUENCE SIMILARITIES: Contains 1 thyroglobulin type-1 domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse spleen tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected MHC class II (I-A/I-E) in 10 µg of mouse spleen tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF33,Anti-MHC class II (I-A/I-E) Antibody, clone M5/114

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