merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9451,Anti-Metabotropic Glutamate Receptor 8 Antibody

  • merck millipore,默克密理博,AB9451,Anti-Metabotropic Glutamate Receptor 8 Antibody

    产品名称：Anti-Metabotropic Glutamate Receptor 8 Antibody
    产品型号：AB9451
    Anti-Metabotropic Glutamate Receptor 8 Antibody detects level of Metabotropic Glutamate Receptor 8 & has been published & validated for use in IH(P).

    merck millipore,默克密理博,AB9451,Anti-Metabotropic Glutamate Receptor 8 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9451,Anti-Metabotropic Glutamate Receptor 8 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIH(P)RbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9451
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Metabotropic Glutamate Receptor 8 Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
    应用
    应用 Anti-Metabotropic Glutamate Receptor 8 Antibody detects level of Metabotropic Glutamate Receptor 8 & has been published & validated for use in IH(P).
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry on paraffin embedded tissue sections.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from the C-terminal domain of human Metabotropic Glutamate Receptor 8.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Metabotropic Glutamate Receptor 8 [mGluR8].
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000845.1
    Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.
    基因符号
    • GPRC1H
    • GRM8
    • GLUR8
    • mGlu8
    • MGLUR8
    • MGC126724
    • mGluR8
    • FLJ41058
    UniProt编号
    • O00222
    UniProt汇总 FUNCTION: SwissProt: O00222 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
    SIZE: 908 amino acids; 101741 Da
    SUBUNIT: Interacts with PRKCABP (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    SIMILARITY: SwissProt: O00222 ## Belongs to the G-protein coupled receptor 3 family.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB9451,Anti-Metabotropic Glutamate Receptor 8 Antibody

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