merck millipore,默克密理博,520222,PPACK, Dihydrochloride - CAS 142036-63-3

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,520222,PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
产品名称：PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
产品型号：520222
Extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹).

merck millipore,默克密理博,520222,PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem

产品介绍

merck millipore,默克密理博,520222,PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem

重要规格表

经验配方	CAS号
C₂₁H₃₃N₆O₃Cl₃	142036-63-3

描述
概述	Extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M^-1S^-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H₂O (Cat. No. 508773).
产品目录编号	520222
品牌系列	Calbiochem®

参考
参考	Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157. Odake S., et al. 1995. J. Enzyme Inhib. 9, 17. Arni, R.K., et al. 1993. Biochemistry 32, 4727. Yamashita, T., et al. 1993. Thromb. Res. 69, 93. Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479. Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76. Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826. Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

参考

Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

产品信息
CAS号	142036-63-3
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₁H₃₃N₆O₃Cl₃
化学配方	C₂₁H₃₃N₆O₃Cl₃
Molar Mass	523.9
吸湿	Hygroscopic
肽序列	H-D-Phe-Pro-Arg-chloromethylketone, 2HCl
可逆	N

生物信息
主靶	Thrombin
主靶IC₅₀	Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
纯度	≥80% by HPLC

理化信息
细胞可渗透	N
溶解度	H₂O
肽序列	H-D-Phe-Pro-Arg-chloromethylketone, 2HCl

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
防潮	Protect from moisture
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.