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merck millipore,默克密理博,178493,Apoptosis Activator III, Embelin - CAS 550-24-3 - Calbiochem
产品名称：Apoptosis Activator III, Embelin - CAS 550-24-3 - Calbiochem
产品型号：178493
The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,178493,Apoptosis Activator III, Embelin - CAS 550-24-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₂₆O₄ 550-24-3 描述 概述 A cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 µM in a competitive binding assay with Smac peptide). Selectively induces caspase-9-mediated apoptosis in prostate cancer cells with high levels of XIAP (IC50 = 3.7 and 5.7 µM for PC-3 and LnCap, respectively), while exhibiting much less effect towards cells with low level XIAP (IC50 = 19.3 and 20.1 µM for WI-38 and PrEC, respectively). Also shown to sensitize XIAP overexpressing Jurkat cells to Etoposide -induced apoptosis. A non-competitive PCAF (p300/CBP associated factor)-specific lysine acetyltransferase (KAT) inhibitor (IC50 = 7.2 µM). 产品目录编号 178493 品牌系列 Calbiochem®
同义词 Embelin, Embelia ribes, XIAP inhibitor, Embelin, 2,5-Dihydroxy-3-undecyl-1,4-benzoquinone 参考 参考 Modak, R., et al. 2013. ACS Chem. Biol. 8, In press.
Nikolovska-Coleska, Z., et al. 2004. J. Med. Chem. 47, 2430.产品信息 CAS号 550-24-3 具有ATP竞争性 N 形式 Orange solid Hill配方 C₁₇H₂₆O₄ 化学配方 C₁₇H₂₆O₄ Molar Mass 294.4 可逆 N 结构配方图像 生物信息 主靶 BIR3 主靶IC50 4.1 µM in antagonizing XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 in a competitive binding assay with Smac peptide 纯度 Single spot by TLC 理化信息 细胞可渗透 Y 溶解度 DMSO or MeOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,605190,Thrombin, Human Plasma
下一件merck millipore产品：merck millipore,默克密理博,648466,TRITON X-100 Detergent, Molecular Biology Grade - CAS 9002-93-1 - Calbiochem
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