merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9448,Anti-Metabotropic Glutamate Receptor 1 Antibody

  • merck millipore,默克密理博,AB9448,Anti-Metabotropic Glutamate Receptor 1 Antibody

    产品名称：Anti-Metabotropic Glutamate Receptor 1 Antibody
    产品型号：AB9448
    Detect Metabotropic Glutamate Receptor 1 using this Anti-Metabotropic Glutamate Receptor 1 Antibody validated for use in IH(P).

    merck millipore,默克密理博,AB9448,Anti-Metabotropic Glutamate Receptor 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9448,Anti-Metabotropic Glutamate Receptor 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIH(P)RbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9448
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Metabotropic Glutamate Receptor 1 Antibody
    Alternate Names
    • mGluR1
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
    应用
    应用 Detect Metabotropic Glutamate Receptor 1 using this Anti-Metabotropic Glutamate Receptor 1 Antibody validated for use in IH(P).
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry on paraffin embedded tissue sections.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from the C-terminal domain of human Metabotropic Glutamate Receptor 1.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Metabotropic Glutamate Receptor 1 [mGluR1].
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000838.2
    Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
    基因符号
    • GPRC1A
    • GRM1
    • mGluR1
    • MGLUR1A
    • GRM1A
    • mGlu1
    • MGLUR1
    UniProt编号
    • Q13255
    UniProt汇总 FUNCTION: SwissProt: Q13255 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
    SIZE: 1194 amino acids; 132367 Da
    SUBUNIT: Homodimer; disulfide-linked. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    SIMILARITY: SwissProt: Q13255 ## Belongs to the G-protein coupled receptor 3 family.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB9448,Anti-Metabotropic Glutamate Receptor 1 Antibody

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