merck millipore,默克密理愽
  • merck millipore,默克密理博,14-306M,GSK3β Protein, active, 250 µg

  • merck millipore,默克密理博,14-306M,GSK3β Protein, active, 250 µg

    产品名称：GSK3β Protein, active, 250 µg
    产品型号：14-306M
    Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.

    merck millipore,默克密理博,14-306M,GSK3β Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-306M,GSK3β Protein, active, 250 µg

    描述
    产品目录编号 14-306M
    品牌系列 Upstate
    商名
    • Upstate
    描述 GSK3β Protein, active, 250 µg
    概述 N-terminal His6-tagged recombinant human GSK3β with an H350L mutation
    应用
    应用 Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002093.2
    Entrez基因汇总 Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).[supplied by OMIM]
    基因符号
    • GSK3B
    蛋白靶 GSK3β
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • P49841
    UniProt汇总 FUNCTION: SwissProt: P49841 # Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA.
    SIZE: 420 amino acids; 46744 Da
    SUBUNIT: Monomer (By similarity). Interacts with NIN and CABYR.
    TISSUE SPECIFICITY: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
    PTM: Phosphorylated by AKT1 and ILK1.
    SIMILARITY: SwissProt: P49841 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-306) and in bulk (cat# 14-306-K).

    merck millipore,默克密理博,14-306M,GSK3β Protein, active, 250 µg

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