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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9772-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SK1 (KCA2.1) Antibody Alternate Names - Small conductance Ca<sup>2+</sup>-activated K<sup>+</sup> Channel 1, SKCa1, KCNN1
- Small conductance Ca<sup>2+</sup>-activated K<sup>+</sup> Channel 1
- SKCa1
产品信息 格式 Affinity Purified 控制 - Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 Detect SK1 (KCA2.1) using this Anti-SK1 (KCA2.1) Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:200 using ECL on rat brain cortex. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. 生物信息 免疫原品种 Purified peptide from amino acids 75-93 of rat SK1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes SK1 (KCA2.1, Small conductance Ca2+-activated K+ Channel 1, SKCa1, KCNN1). 品种反应性 Rat Species Reactivity Note The immunogen sequence is 17 of 19 amino acids identical in mouse and 12 of 19 amino acids identical in human. 抗体类型 Polyclonal Antibody Entrez基因汇总 Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. 基因符号 - KCNN1
- SK1
纯化方法 Immunoaffinity purified UniProt编号 - Q92952
- P70606
UniProt汇总 FUNCTION: SwissProt: Q92952 # Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
SIZE: 543 amino acids; 59987 Da
SUBUNIT: Hetero-oligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: Q92952 ## Belongs to the potassium channel KCNN family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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