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品种反应性 主要应用 宿主 格式 抗体类型 H IH(P) Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9410 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Adrenoceptor β-2 Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide. 应用 应用 Anti-Adrenoceptor Antibody, β-2 is an antibody against Adrenoceptor for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections.
Immunocytochemistry on acetone-fixed cells.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from the C-terminal domain of human Adrenoceptor, Beta-2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Adrenoceptor, Beta-2. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000024.4
Entrez基因汇总 This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. 基因符号 - ADRB2R
- ADRB2
- B2AR
- BAR
- BETA2AR
- ADRBR
UniProt编号 - P07550
UniProt汇总 FUNCTION: SwissProt: P07550 # Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
SIZE: 413 amino acids; 46557 Da
SUBUNIT: Binds SLC9A3R1 and GPRASP1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser- 346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. & Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA- mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: P07550 # Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.
SIMILARITY: SwissProt: P07550 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 销售限制 This product is not available for sale in Japan. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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