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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-449 Replaces MAB4131 品牌系列 Upstate
商名 - Upstate
描述 Anti-Bin1 Antibody, clone 99D 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, containing 0.05% sodium azide 应用 应用 Anti-Bin1 Antibody, clone 99D is an antibody against Bin1 for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Partial fusion protein corresponding to amino acids 189-398 of human Bin1. Clone 99D 克隆 clone 99D 宿主 Mouse 特异性 Bin1 同种型 IgG1κ 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_139343
Entrez基因汇总 This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. 基因符号 - SH3P9
- BIN1
- AMPH2
- amphiphysin-like
- MGC10367
- DKFZp547F068
- AMPHL
纯化方法 Protein G chromatography UniProt编号 - O00499
UniProt汇总 FUNCTION: SwissProt: O00499 # May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
SIZE: 593 amino acids; 64699 Da
SUBUNIT: Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Binds to SYNJ1 and DNM1 through its SH3 domain, and to clathrin through a region outside of the SH3 domain. Also binds AP2A2. Interacts with the N-terminal transactivation domain of MYC in a manner requiring the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts with HCV NS5A through its SH3 domain.
SUBCELLULAR LOCATION: Isoform BIN1: Nucleus. & Isoform IIA: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
PTM: Phosphorylated by protein kinase C (By similarity).
DISEASE: "SwissProt: O00499 # Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers."
SIMILARITY: SwissProt: O00499 ## Contains 1 BAR domain. & Contains 1 SH3 domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysate of C2C12 cells. 销售限制 Due to license agreement restrictions, this product cannot be purchased for resale. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 200 µg
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