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  • merck millipore,默克密理博,AB6050,Anti-Kinesin-like protein KIF2A Antibody

  • merck millipore,默克密理博,AB6050,Anti-Kinesin-like protein KIF2A Antibody

    产品名称：Anti-Kinesin-like protein KIF2A Antibody
    产品型号：AB6050
    Anti-Kinesin-like protein KIF2A Antibody detects level of Kinesin-like protein KIF2A & has been published & validated for use in WB & IC.

    merck millipore,默克密理博,AB6050,Anti-Kinesin-like protein KIF2A Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB6050,Anti-Kinesin-like protein KIF2A Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB6050
    描述 Anti-Kinesin-like protein KIF2A Antibody
    Alternate Names
    • hK2
    • Kinesin-like protein KIF2A
    • Kinesin-2
    背景信息 The kinesin-like protein KIF2A is a microtubule-depolymerizing KinK motor that stifles the elongation of axon collaterals and seems to be expressed in the centrosomes and spindle poles of cells during mitosis. KIF2A activity must balance MCAK activity to assure spindle bipolarity. Increased expression of KIF2A has been linked to an increase in progression, invasion and metastasis of squamous cell carcinoma of the oral tongue and may also be an indicator of patient prognosis.
    产品信息
    格式 Affinity Purified
    控制
    • NIH/3T3 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Kinesin-like protein KIF2A Antibody detects level of Kinesin-like protein KIF2A & has been published & validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A previous lot of this antibody detected KIF2A in the mitotic spindles and the spindle core of serum-starved HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human Kinesin-like protein KIF2A.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Kinesin-like protein KIF2A at the C-terminus.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001091981
    Entrez基因汇总 Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM].
    基因符号
    • KNS2
    • KIF2A
    • KIF2
    纯化方法 Affinity purified
    UniProt编号
    • O00139
    UniProt汇总 FUNCTION: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

    SUBUNIT STRUCTURE: Interacts with AURKA, PSRC1 and PLK1.

    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle pole. Cytoplasm › cytoskeleton › spindle. Note: Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.

    MISCELLANEOUS: HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.

    SEQUENCE SIMLARITIES: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.

    Contains 1 kinesin-motor domain.

    SEQUENCE CAUTION: The sequence AAP84320.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Kinesin-like protein KIF2A in 10 µg of NIH/3T3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB6050,Anti-Kinesin-like protein KIF2A Antibody

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