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经验配方 CAS号 C₂₃H₂₈ClN₃O₅S 10238-21-8 描述 概述 A sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide. 产品目录编号 356310 品牌系列 Calbiochem®
同义词 Glybenclamide 参考 参考 Holzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.产品信息 CAS号 10238-21-8 具有ATP竞争性 N 形式 White solid Hill配方 C₂₃H₂₈ClN₃O₅S 化学配方 C₂₃H₂₈ClN₃O₅S Molar Mass 494.0 可逆 N 结构配方图像 生物信息 主靶 ATP-sensitive K+ channels 纯度 ≥98% by TLC 理化信息 细胞可渗透 N 溶解度 DMSO or EtOH (slightly) GHS安全信息 RTECS YS4725200 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +15°C to +30°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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