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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB16528 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NIK Antibody, CT Alternate Names - NFkB inducing Kinase
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Anti-NIK Antibody, C-terminus is an antibody against NIK for use in WB. 主要应用 - Western Blotting
应用说明 Western blot
293 cell lysate can be used as positive control.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rabbit anti-NIK polyclonal antibody was raised against a peptide corresponding to amino acids 931 to 947 of human NIK (Malinin et al. 1997). 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kB activation by IL-1, TNFa and CD95 was identified recently and designated NIK (for NF-kB inducing kinase) (Malinin et al. 1997). NIK is an activator of IkB kinase alpha and beta (IKKalpha and IKKbeta) (Regnier et al. 1997; Woronicz et al. 1997; Ling et al. 1998; Nakano et al. 1998). Therefore, NIK is a key molecule in the NF-kB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003954.2
Entrez基因汇总 This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. 基因符号 - EC 2.7.11.25
- MAP3K14
- hsNIK
- FTDCR1B
- HSNIK
- HS
- NIK
- HsNIK
UniProt编号 - Q99558
UniProt汇总 FUNCTION: SwissProt: Q99558 # Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity).
SIZE: 947 amino acids; 104042 Da
SUBUNIT: Binds to TRAF2, TRAF5, TRAF6, IKKA and NF-kappa-B 2/P100 (By similarity). Interacts with PELI3.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
PTM: Autophosphorylated.
SIMILARITY: SwissProt: Q99558 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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