merck millipore,默克密理愽
  • merck millipore,默克密理博,124018,Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem

  • merck millipore,默克密理博,124018,Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem

    产品名称：Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
    产品型号：124018
    The Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, also referenced under CAS 612847-09-3, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation More>>

    merck millipore,默克密理博,124018,Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124018,Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₄H₂₉N₇O612847-09-3
    描述
    概述 A cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 µM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. A 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124017) in DMSO is also available.
    产品目录编号 124018
    品牌系列 Calbiochem®
    同义词 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2
    参考
    参考 Calleja, V., et al. 2009. PLoS Biol. 7, e17.
    Logie, L., et al. 2007. Diabetes 56, 228.
    Barnett, S.F., et al. 2005. Biochem. J. 385, 399.
    DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
    Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
    Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.
    产品信息
    CAS号 612847-09-3
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₃₄H₂₉N₇O
    化学配方 C₃₄H₂₉N₇O
    Molar Mass 551.6
    可逆 Y
    结构配方图像
    生物信息
    主靶 Akt1, Akt2, Akt3
    主靶IC50 58 nM, 210 nM, 2.12 µM against Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124018,Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem

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