merck millipore,默克密理愽
  • merck millipore,默克密理博,AB6033,Anti-End-binding protein 3 (EB3) Antibody

  • merck millipore,默克密理博,AB6033,Anti-End-binding protein 3 (EB3) Antibody

    产品名称：Anti-End-binding protein 3 (EB3) Antibody
    产品型号：AB6033
    Detect End-binding protein 3 (EB3) using this Anti-End-binding protein 3 (EB3) Antibody validated for use in WB & IC.

    merck millipore,默克密理博,AB6033,Anti-End-binding protein 3 (EB3) Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB6033,Anti-End-binding protein 3 (EB3) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, HICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB6033
    描述 Anti-End-binding protein 3 (EB3) Antibody
    Alternate Names
    • APC binding protein
    • microtubule-associated protein, RP/EB family, member 3
    • EB1 protein family member 3
    • microtubule-associated protein RP/EB family member 3
    • End-binding protein 3
    背景信息 EB (End-binding) proteins are evolutionarily conserved and are important for extending tips of microtubules as well as regulating microtubule dynamics and communication with other intracellular substances. End-binding protein 3 (also known as EB3 or Microtubule-associated protein RP/EB family member 3) is a 282 amino acid long protein that is 53% homologous to EB1, which is known to associate with adenomatous polyposis coli tumor suppressor. EB3 has been shown to prefer brain tissue. EB3 is highly expressed during myogenic differentiation and the loss of EB3 activity leads to the inability of myoblasts to elongate and combine into microtubules. EB3 may be involved in microtubule polymerization and cell migration. EB3 may be also involved in stabilizing microtubules and anchoring them to centrosomes during spindle formation.
    产品信息
    格式 Affinity Purified
    控制
    • MCF-7 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect End-binding protein 3 (EB3) using this Anti-End-binding protein 3 (EB3) Antibody validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect EB3 in MCF-7 cells (Dr. Anna Akhmanova, Erasmus Medical Center).

    Immunoprecipitation Analysis: A previous lot of this antibody immunoprecipitated EB3 from COS-7 cell lysates (Worth, D.C., et al. (2013) J. Cell Biol. Vol. 202 No. 5 793–806).
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human EB3.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Detects EB3, but may show slight cross reactivity with EB1.
    品种反应性 MonkeyHuman
    Species Reactivity Note Demonstrated to react with human.
    EB1 (67% sequence homology). Mouse EB3 (99% sequence homology). Rat EB3 (98% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_036458
    Entrez基因汇总 The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq].
    基因符号
    • MAPRE3
    • EB3
    • RP3
    • EBF3-S2
    • EBF3
    纯化方法 Affinity Purified
    UniProt编号
    • Q9UPY8
    UniProt汇总 FUNCTION: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

    SUBUNIT STRUCTURE: Interacts with APC2 (By similarity). Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.

    SUBCELLULAR LOCATION: Cytoplasm. Note: Associated with the microtubule network. Ref.1

    DOMAIN: Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.

    SEQUENCE SIMILARITIES: Belongs to the MAPRE family.

    Contains 1 CH (calponin-homology) domain.

    Contains 1 EB1 C-terminal domain.

    SEQUENCE CAUTION: The sequence AAK07556.1 differs from that shown. Reason: Erroneous initiation.

    The sequence AAK07557.1 differs from that shown. Reason: Erroneous initiation.

    The sequence CAA72060.1 differs from that shown. Reason: Frameshift at position 199.
    产品使用声明
    质量保证 Evaluated by Western Blot in MCF-7 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected EB3 in 10 µg of MCF-7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB6033,Anti-End-binding protein 3 (EB3) Antibody

上一件merck millipore产品：merck millipore,默克密理博,CBL468F,Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated
下一件merck millipore产品：merck millipore,默克密理博,14-474,PRMT1 Protein, active, N-terminal GST-tagged, 25 µg


相关产品

merck millipore,默克密理博,20-309,0.1M MnCl2 merck millipore,默克密理博,20-309,0.1M MnCl2

merck millipore,默克密理博,GF170,DKK-1 Protein, Human Recombinant merck millipore,默克密理博,GF170,DKK-1 Protein, Human Recombinant

merck millipore,默克密理博,17-10408,Di-Ubiquitin (Lys48-linked) Recombinant Protein merck millipore,默克密理博,17-10408,Di-Ubiquitin (Lys48-linked) Recombinant Protein

merck millipore,默克密理博,MABN516,Anti-TARPGamma2/4/8 Antibody, clone N245/36 merck millipore,默克密理博,MABN516,Anti-TARPGamma2/4/8 Antibody, clone N245/36

merck millipore,默克密理博,CBL468F,Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated merck millipore,默克密理博,CBL468F,Anti-PECAM-1 Antibody, clone HC1/6, FITC conjugated

merck millipore,默克密理博,14-474,PRMT1 Protein, active, N-terminal GST-tagged, 25 µg merck millipore,默克密理博,14-474,PRMT1 Protein, active, N-terminal GST-tagged, 25 µg

merck millipore,默克密理博,14-452M,PDK1 Protein, active, 250 µg merck millipore,默克密理博,14-452M,PDK1 Protein, active, 250 µg

merck millipore,默克密理博,574777,Anti-Synapsin I Rabbit pAb merck millipore,默克密理博,574777,Anti-Synapsin I Rabbit pAb

merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody

merck millipore,默克密理博,219671,CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem merck millipore,默克密理博,219671,CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部