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  • merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody

  • merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody

    产品名称：Anti-RNF2 (Ring1b) Antibody
    产品型号：09-723
    Use Anti-RNF2 (Ring1b) Antibody (rabbit polyclonal antibody) validated in WB to detect RNF2 (Ring1b) also known as DinG protein ,Huntingtin-interacting protein 2-interacting protein 3, RING finger pro More>>

    merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ca, H, M, R, B, ChWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 09-723
    描述 Anti-RNF2 (Ring1b) Antibody
    Alternate Names
    • ring finger protein 2
    • DinG protein
    • HIP2-interacting protein 3
    • Huntingtin-interacting protein 2-interacting protein 3
    • RING finger protein 1B
    • RING finger protein BAP-1
    背景信息 RNF2 (ring finger 2), also known as Ring1b, is one of the polycomb groups of proteins, which are important for proper development and stem cell renewal. These proteins form complexes that are essential for the transcriptional repression of genes involved in cell proliferation. This is done through post-translational modification and binding to histones. RNF2 is a critical component of that process. Changes in the expression of these proteins have been linked to cancer. RNF2 has been shown to interact with huntingtin interacting protein 2 (HIP2), a ubiquitin-conjugating enzyme. Studies have also shown that RNF2 is able to suppress the activity of transcription factor CP2.
    产品信息
    格式 Affinity Purified
    控制
    • NIH/3T3 cell lysate
    演示 Purified rabbit polyclonal containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide.
    应用
    应用 Use Anti-RNF2 (Ring1b) Antibody (rabbit polyclonal antibody) validated in WB to detect RNF2 (Ring1b) also known as DinG protein ,Huntingtin-interacting protein 2-interacting protein 3, RING finger protein BAP-1 .
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis: 1 µg/mL from a previous lot detected RNF2 (Ring1b) in 10 µg of human brain tissue lysate.
    Western Blot (SNAP ID) Analysis:
    1.5 µg/mL from a previous lot detected RNF2 (Ring1b) in 10 µg of NIH/3T3 cell lysate.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human RNF2 (Ring1b).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes RNF2 (Ring1b).
    品种反应性 CanineHumanMouseRatBovineChicken
    Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with chicken, canine (dog), and bovine (cow) based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_009143.1
    Entrez基因汇总 Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
    基因符号
    • RING2
    • BAP-1
    • BAP1
    • DING
    • EC 6.3.2.-
    • HIPI3
    • OTTHUMP00000033405
    • OTTHUMP00000060668
    • RING1B
    • RING1b
    纯化方法 Affinity Purfied
    UniProt编号
    • Q99496
    UniProt汇总 FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 and BMI1/PCGF4 may rather act as a modulator of RNF2/RING2 activity.
    PATHWAY: Protein modification; protein ubiquitination.
    SUBUNIT STRUCTURE: Component of some chromatin-associated Polycomb complex (PcG). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2. Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with RYBP, HIP2 and TFCP2. Association to the chromosomal DNA is cell-cycle dependent. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RING1. SUBCELLULAR LOCATION: Nucleus By similarity. Note: Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells By similarity.
    SEQUENCE SIMILARITIES: Contains 1 RING-type zinc finger.
    SEQUENCE CAUTIION: The sequence CAI17849.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI17850.1 differs from that shown. Reason: Erroneous gene model prediction.
    产品使用声明
    质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
    Western Blot Analysis: 0.5-1 µg/mL of this antibody detected RNF2 (Ring1b) in 10 µg of NIH/3T3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable at 2-8°C for 1 year from date of recepit.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody

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