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merck millipore,默克密理博,219671,CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem
产品名称：CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem
产品型号：219671
The CFTR Inhibitor II, GlyH-101, also referenced under CAS 328541-79-3, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,219671,CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₅Br₂N₃O₃ 328541-79-3 描述 概述 A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 219675). 产品目录编号 219671 品牌系列 Calbiochem®
同义词 N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide 参考 参考 Sonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.产品信息 CAS号 328541-79-3 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₉H₁₅Br₂N₃O₃ 化学配方 C₁₉H₁₅Br₂N₃O₃ Molar Mass 493.2 可逆 Y 结构配方图像 生物信息 主靶 CFTR 主靶IC50 95% inhibition at 50 µM 主靶Ki 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
上一件merck millipore产品：merck millipore,默克密理博,09-723,Anti-RNF2 (Ring1b) Antibody
下一件merck millipore产品：merck millipore,默克密理博,555558,Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem
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