merck millipore,默克密理愽
  • merck millipore,默克密理博,555558,Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

  • merck millipore,默克密理博,555558,Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

    产品名称：Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem
    产品型号：555558
    The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applicat More>>

    merck millipore,默克密理博,555558,Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,555558,Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₃ClF₆N₂O₃285986-88-1
    描述
    概述 A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 ≤300 nM) and block RhoC/ Gα12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM.
    产品目录编号 555558
    品牌系列 Calbiochem®
    同义词 N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
    参考
    参考 Lundquist, M.R., et al. 2014. Cell 156, 563..
    Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.
    产品信息
    CAS号 285986-88-1
    形式 White solid
    Hill配方 C₁₈H₁₃ClF₆N₂O₃
    化学配方 C₁₈H₁₃ClF₆N₂O₃
    Molar Mass 454.8
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,555558,Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,219671,CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,100105,A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem


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