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merck millipore,默克密理博,GF170,DKK-1 Protein, Human Recombinant
产品名称：DKK-1 Protein, Human Recombinant
产品型号：GF170
The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.
merck millipore,默克密理博,GF170,DKK-1 Protein, Human Recombinant
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重要规格表
来源 纯度 HEK293 Cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses 描述 产品目录编号 GF170 描述 DKK-1 Protein, Human Recombinant Alternate Names - SK
- Dickkopf related protein 1
- DKK1
- DKK
背景信息 Dickkopf related protein 1 (Dkk1) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4, and a related protein, Soggy. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues. 产品信息 演示 Product is filtered through a 0.2 micron filter before lyophilization. 应用 应用 The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy. 生物信息 纯度 Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses 来源 HEK293 Cells 交叉反应性 None UniProt编号 - O94907
产品使用声明 质量保证 Bioactivity assay: Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml. 储存和货运信息 存储条件 Store at -20°C for up to 6 months from date of receipt. 包装信息 数量 10 µg
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