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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Unpurified Polyclonal Antibody 描述 产品目录编号 AB6021 描述 Anti-Stabilin-1 Antibody, CT Alternate Names - stabilin 1
- Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
- MS-1 antigen
- common lymphatic endothelial and vascular endothelial receptor-1
- fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1
背景信息 Stabilin-1 and Stabilin-2 constitute a novel family of fasciclin domain-containing hyaluronan receptor homologs that may play a role in cell-cell and cell-extracellular matrix interactions in vascular function and inflammatory processes. Stabilin-1 is a transmembrane protein, expressed in endothelial cells within the sinusoidal regions of liver, spleen, and lymph tissues as well as macrophages. Stabilin-2 is absent from the latter (Politz, 2002). 产品信息 格式 Unpurified 控制 - HUVEC lysate.
演示 Unpurified rabbit polyclonal in serum with 0.05% sodium azide. 应用 应用 Anti-Stabilin-1 Antibody, C-terminus is an antibody against Stabilin-1 for use in WB, IH(P) & IF. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Stabilin-1 in human placental tertiary villi.
Immunofluorescence Analysis: A previous lot of Anti-Stabilin-1, C-terminus was shown to positively stain using immunofluorescence techniques (Kzhyshkowska, 2008).生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of human Stabilin-1. 表位 C-terminus 宿主 Rabbit 特异性 The antibody recognizes the C-terminus of Stabilin-1 within the cytoplasmic region of a cell. 品种反应性 Human Species Reactivity Note Demonstrated to react with human. Other notable species homologies include mouse (87%) and rat (83%). 抗体类型 Polyclonal Antibody Entrez基因编号 - Q9NY15
基因符号 - STAB-1
- CLEVER-1
- FEEL-1
- FEEL1
- FELE-1
- FEX1
- KIAA0246
纯化方法 Unpurified UniProt编号 - Q9NY15
UniProt汇总 FUNCTION: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
SUBUNIT STRUCTURE: Interacts with CHID1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.
TISSUE SPECIFICITY: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
SEQUENCE SIMILARITIES: Contains 16 EGF-like domains.
Contains 7 FAS1 domains.
Contains 2 laminin EGF-like domains.
Contains 1 Link domain.产品使用声明 质量保证 Evaluated by Western blot in HUVEC lysate.
Western blot Analysis: 1:1,000 dilution of this antibody detected Stabilin-1 on 10 µg of HUVEC lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt if stored in undiluted aliquots.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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