merck millipore,默克密理愽
  • merck millipore,默克密理博,03-34-0051,Calpeptin - CAS 117591-20-5 - Calbiochem

  • merck millipore,默克密理博,03-34-0051,Calpeptin - CAS 117591-20-5 - Calbiochem

    产品名称：Calpeptin - CAS 117591-20-5 - Calbiochem
    产品型号：03-34-0051
    A cell-permeable calpain inhibitor (ID₅₀ = 52 nM for calpain-1; ID₅₀ = 34 nM for calpain-2; ID₅₀ = 138 nM for papain).

    merck millipore,默克密理博,03-34-0051,Calpeptin - CAS 117591-20-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,03-34-0051,Calpeptin - CAS 117591-20-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₃₀N₂O₄117591-20-5
    描述
    概述 A cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
    产品目录编号 03-34-0051
    品牌系列 Calbiochem®
    同义词 Benzyloxycarbonylleucyl-norleucinal
    参考
    参考 Lee, M.S., et al. 2000. Nature 405, 360.
    Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
    Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
    Shiba, E., et al. 1996. Anticancer Res. 16, 773.
    Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
    Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
    Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
    产品信息
    CAS号 117591-20-5
    具有ATP竞争性 N
    形式 White to off-white solid
    Hill配方 C₂₀H₃₀N₂O₄
    化学配方 C₂₀H₃₀N₂O₄
    Molar Mass 362.5
    肽序列 Z-Leu-Nle-CHO
    可逆 N
    结构配方图像
    生物信息
    主靶 Calpain-1
    主靶IC50 ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
    纯度 ≥94% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or DMF
    肽序列 Z-Leu-Nle-CHO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,03-34-0051,Calpeptin - CAS 117591-20-5 - Calbiochem

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