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  • merck millipore,默克密理博,AB5832,Anti-BACE Antibody

  • merck millipore,默克密理博,AB5832,Anti-BACE Antibody

    产品名称：Anti-BACE Antibody
    产品型号：AB5832
    Anti-BACE Antibody is an antibody against BACE for use in WB.

    merck millipore,默克密理博,AB5832,Anti-BACE Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5832,Anti-BACE Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5832
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-BACE Antibody
    Alternate Names
    • beta-Site APP Cleaving Enzyme
    • ASP2
    • BACE1
    • Beta Secretase
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide.
    应用
    应用 Anti-BACE Antibody is an antibody against BACE for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blotting: 0.5-1.0 μg/mL on human brain tissue. The antibody recognizes a protein of molecular weight of 70 kDa in normal human brain lysate.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 458 to 501 of human BACE (Vassar et al. 1999).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Reacts with human BACE by Western blot.
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_138973.2
    • NM_012104.3
    • NM_138971.2
    • NM_138972.2
    Entrez基因汇总 Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
    基因符号
    • EC 3.4.23.46
    • BACE1
    • ASP2
    • beta-secretase
    • KIAA1149
    • Memapsin-2
    • BACE
    • memapsin-2
    • HSPC104
    • FLJ90568
    UniProt编号
    • P56817
    UniProt汇总 FUNCTION: SwissProt: P56817 # Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
    SIZE: 501 amino acids; 55764 Da
    SUBUNIT: Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Brain.
    SIMILARITY: SwissProt: P56817 ## Belongs to the peptidase A1 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5832,Anti-BACE Antibody

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