- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
经验配方 CAS号 C₇₀H₁₃₁N₁₉O₁₅ 72093-21-1 描述 概述 A cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca2+. Acts as a calmodulin antagonist and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum. Also reported to inhibit Na+,K+-ATPase activity (IC50 = 7.5 µM). 产品目录编号 444898 品牌系列 Calbiochem®
同义词 INLKALAALAKKIL 参考 参考 Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
Liz, S.Z., et al. 1997. Brain Res. 771, 184.
Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
Langel, U., et al. 1996. Regul. Peptides 62, 47.
Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
Igarashi, M., et al. 1993. Science 259, 77.
Komatsu, M., et al. 1992. Endocrinology 130, 221.
Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
Gil, J., et al. 1991. J. Cell Biol. 113, 943.产品信息 CAS号 72093-21-1 具有ATP竞争性 N 形式 White solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₇₀H₁₃₁N₁₉O₁₅ 化学配方 C₇₀H₁₃₁N₁₉O₁₅ Molar Mass 1478.9 肽序列 H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂ 可逆 N 基于肽含量售出 Yes
生物信息 主靶 Na+,K+-ATPase activity 主靶IC50 7.5 µM 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 H₂O 肽含量 Yes
肽序列 H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂ 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
上一件merck millipore产品：merck millipore,默克密理博,SF-171,MLH1; Human, Cyanine 5, RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,324744,Elastase Inhibitor II - Calbiochem
相关产品
merck millipore,默克密理博,AB9352,Anti-Po Antibody
merck millipore,默克密理博,MAB3854,Anti-Adiponectin Antibody, clone RADI 06
merck millipore,默克密理博,14-571M,TrkA Protein, active, 250 µg
merck millipore,默克密理博,203781,5-Bromo-4-chloro-3-indolyl-α-D-glucopyranoside
merck millipore,默克密理博,SF-171,MLH1; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,324744,Elastase Inhibitor II - Calbiochem
merck millipore,默克密理博,AP200,Goat Anti-Mouse light chain Antibody
merck millipore,默克密理博,AB5832,Anti-BACE Antibody
merck millipore,默克密理博,AB1837P,Anti-Tumor Necrosis Factor-α Antibody
