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品种反应性 主要应用 宿主 格式 抗体类型 F, B, H, R, Sh WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB5467 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-AANAT Antibody Alternate Names - EC 2.3.1.87
- Serotonin Acetylase
- SNAT
- Arylalkylamine N-acetyltransferase
产品信息 格式 Serum 控制 - POSITIVE CONTROL:
Night adapted rat pineal gland. Expression is light sensitive; highest levels are obtained from animals at night.
演示 Liquid rabbit serum containing no preservative. 应用 应用 Anti-AANAT Antibody is an antibody against AANAT for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot: 1:10,000-1:20,000 using ECL. Reacts with the ~23 kDa AANAT protein. Some reactivity may also be seen at ~97 kDa. Suggested blocking buffer is PBS with 10% non fat dry milk and 0.2% Tween-20. Suggested dilution buffer is PBS with 1 mg/mL BSA fraction V. Suggested incubation time is overnight at room temperature (~23°C).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide (phosphorylated) corresponding to amino acids near the N-terminous of rat AANAT conjugated to BSA. {Ganguly, S et al, 2005}. 宿主 Rabbit 特异性 Recognizes AANAT (Arylalkylamine N-acetyltransferase). The antibody specifically recognizes the phosphorylated N-terminal PKA site of AANAT (pT31) (Ganguly et al. 2005). The antibody reacts with natural and recombinant protein. 品种反应性 FishBovineHumanRatSheep 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001088.1
Entrez基因汇总 Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle. 基因符号 - EC 2.3.1.87
- AANAT
- SNAT
- AA-NAT
UniProt编号 - Q16613
UniProt汇总 FUNCTION: SwissProt: Q16613 # Catalyzes the N-acetylation of serotonin into N- acetylserotonin.
SIZE: 207 amino acids; 23344 Da
SUBUNIT: Monomer (By similarity).
TISSUE SPECIFICITY: Highly expressed in pineal gland and retina.
SIMILARITY: SwissProt: Q16613 ## Belongs to the acetyltransferase family. AANAT subfamily. & Contains 1 N-acetyltransferase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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