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品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5453 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-GABA A Receptor α6 Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. 应用 应用 Anti-GABA A Receptor α6 Antibody detects level of GABA A Receptor α6 & has been published & validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot: 1:1,000
Immunopreciptation: The antibody will immunoprecipitate 53% of all GABA A receptors in sodium dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 MBP fusion protein from the cytosolic loop of rat GABA A receptor alpha6 subunit. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 GABA A receptor alpha6 subunit. The apparent molecular mass of the alpha6 subunit in rat brain membrane fractions is 56-57 kDa. The antibody shows no reactivity in the forebrain of alpha6 knockout mice. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000811.2
Entrez基因汇总 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. 基因符号 - GABA
- GABRA6
- MGC116903
- MGC116904
UniProt编号 - Q16445
UniProt汇总 FUNCTION: SwissProt: Q16445 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SIZE: 453 amino acids; 51024 Da
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: Q16445 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. 包装信息 数量 100 µL
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