merck millipore,默克密理博,208665,Calmidazolium Chloride - CAS 57265-65-3

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merck millipore,默克密理博,208665,Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem
产品名称：Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem
产品型号：208665
A cell-permeable calmodulin antagonist.

merck millipore,默克密理博,208665,Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem

产品介绍

merck millipore,默克密理博,208665,Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem

重要规格表

经验配方	CAS号
C₃₁H₂₃Cl₇N₂O	57265-65-3

描述
概述	A cell-permeable calmodulin antagonist. At least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain calmodulin-dependent phosphodiesterase (IC₅₀ = 10 nM). An inhibitor of voltage-gated Ca²⁺ channels. Stimulates the release of nitric oxide in neuroblastoma cells. Also acts as a strong non-competitive inhibitor of skeletal muscle sarcoplasmic reticulum Ca²⁺-ATPase (K_i = 60 nM). Known to prolong cardiac refractoriness in vivo.
概述	Note: easily adheres to glass in aqueous solution.
产品目录编号	208665
品牌系列	Calbiochem®
同义词	Compound R 24571

参考
参考	Hu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198. Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137. Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175. Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211. Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675. Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487. Gietzen, L., et al. 1982. Biochem. J. 207, 541. Van Belle, H. 1981. Cell Calcium 2, 483. Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.

参考

Hu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
Gietzen, L., et al. 1982. Biochem. J. 207, 541.
Van Belle, H. 1981. Cell Calcium 2, 483.
Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.

产品信息
CAS号	57265-65-3
具有ATP竞争性	N
形式	White solid
Hill配方	C₃₁H₂₃Cl₇N₂O
化学配方	C₃₁H₂₃Cl₇N₂O
Molar Mass	687.7
可逆	N
结构配方图像

生物信息
主靶	brain calmodulin-dependent phosphodiesterase
主靶IC₅₀	10 nM against brain calmodulin-dependent phosphodiesterase
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.