merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5388,Anti-Synphilin-1 Antibody, a.a. 829-847

  • merck millipore,默克密理博,AB5388,Anti-Synphilin-1 Antibody, a.a. 829-847

    产品名称：Anti-Synphilin-1 Antibody, a.a. 829-847
    产品型号：AB5388
    Anti-Synphilin-1 Antibody, a.a. 829-847 detects level of Synphilin-1 & has been published & validated for use in IH.

    merck millipore,默克密理博,AB5388,Anti-Synphilin-1 Antibody, a.a. 829-847

  • 产品介绍
  • merck millipore,默克密理博,AB5388,Anti-Synphilin-1 Antibody, a.a. 829-847

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HIHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5388
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Synphilin-1 Antibody, a.a. 829-847
    Alternate Names
    • Alpha-Synuclein Interacting Protein
    产品信息
    格式 Serum
    演示 Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
    应用
    应用 Anti-Synphilin-1 Antibody, a.a. 829-847 detects level of Synphilin-1 & has been published & validated for use in IH.
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry: 1:1,000-1:2,000.

    Note: The antibody has also been used successfully for Western blot but results may vary from lab to lab. The usefulness of the antibody for Western blot must be determined by each individual laboratory.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 A synthetic peptide from human synphilin-1 (amino acids 829-847).
    表位 a.a. 829-847
    宿主 Rabbit
    特异性 Synphilin-1. Immunohistochemical analysis of human brain indicates a high level of specificity. Peptide sequence used shows 88% sequence homology with mouse synphilin-1 but mouse has not been tested for reactivity.
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005460.2
    Entrez基因汇总 This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but their full-length nature has yet to be determined.
    基因符号
    • Synphilin-1
    • SNCAIP
    • MGC39814
    • synphilin-1
    • SYPH1
    UniProt编号
    • Q9Y6H5
    UniProt汇总 SIZE: 919 amino acids; 100381 Da
    SUBUNIT: Associates with SNCA, RNF19A AND PARK2.
    TISSUE SPECIFICITY: Widely expressed, with highest levels in brain, heart and placenta.
    PTM: Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation.
    DISEASE: SwissProt: Q9Y6H5 # Defects in SNCAIP are a cause of Parkinson disease (PD) [MIM:168600]. PD is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early- onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
    SIMILARITY: SwissProt: Q9Y6H5 ## Contains 6 ANK repeats.
    MISCELLANEOUS: Constructs encoding portions of SNCA and SNCAIP co- transfected in mammalian cells promote cytosolic inclusions resembling the Lewy bodies of Parkinson disease. Coexpression of SNCA, SNCAIP, and PARK2 result in the formation of Lewy body-like ubiquitin-positive cytosolic inclusions. Familial mutations in PARK2 disrupt the ubiquitination of SNCAIP and the formation of the ubiquitin-positive inclusions. These results provide a molecular basis for the ubiquitination of Lewy body-associated proteins and link PARK2 and SNCA in a common pathogenic mechanism through their interaction with SNCAIP.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5388,Anti-Synphilin-1 Antibody, a.a. 829-847

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