merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5174,Anti-Potassium Channel Kv1.1 Antibody

  • merck millipore,默克密理博,AB5174,Anti-Potassium Channel Kv1.1 Antibody

    产品名称：Anti-Potassium Channel Kv1.1 Antibody
    产品型号：AB5174
    Anti-Potassium Channel Kv1.1 Antibody detects level of Potassium Channel Kv1.1 & has been published & validated for use in IH, IP & WB.

    merck millipore,默克密理博,AB5174,Anti-Potassium Channel Kv1.1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5174,Anti-Potassium Channel Kv1.1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5174
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel Kv1.1 Antibody
    产品信息
    格式 Affinity Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 120 μg of control antigen (lyophilized powder in phosphate buffered saline, pH 7.4, containing 5% sucrose and 0.025% sodium azide). The stock solution of the antigen can be made up using 200 μL of sterile deionized water. For positive control, in Western blot using 40 ng of protein per lane. For negative control, preincubate 3-5 μg of fusion protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Anti-Potassium Channel Kv1.1 Antibody detects level of Potassium Channel Kv1.1 & has been published & validated for use in IH, IP & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:200 using ECL; detects ~ 86kDa band on mouse membranes; some smaller minor bands may also be present. Mature channels are glycosylasted which can lead to smeary or slightly larger bands in certain preparations. It is important to use a full range of proteinase inhbitors to obtain full length protein blots.

    Immunohistochemistry on rat brain sections.

    Immunoprecipitation

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 GST fusion protein and a C-terminal portion of mouse Kv1.1 protein (amino acids 416-495) (Accession P16388).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes a full length Kv1.1 protein. Does not cross react with any other potassium channel antigens tested so far.
    品种反应性 RatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000217.2
    Entrez基因汇总 This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).
    基因符号
    • MGC138385
    • KCNA1
    • HUK1
    • HUKI
    • MGC126782
    • MBK1
    • Kv1.1
    • RBK1
    • HBK1
    • AEMK
    • EA1
    • KV1.1
    • MK1
    UniProt编号
    • Q09470
    UniProt汇总 FUNCTION: SwissProt: Q09470 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    SIZE: 495 amino acids; 56542 Da
    SUBUNIT: Heterotetramer of potassium channel proteins. Binds KCNAB2 and PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DOMAIN: SwissProt: Q09470 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    PTM: Palmitoylated on Cys-243; which may be required for membrane targeting.
    DISEASE: SwissProt: Q09470 # Defects in KCNA1 are the cause of myokymia with periodic ataxia (AEMK) [MIM:160120]; also known as paroxysmal or episodic ataxia with myokymia (EAM) or episodic ataxia type 1 (EA-1). AEMK is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent.
    SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB5174,Anti-Potassium Channel Kv1.1 Antibody

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