merck millipore,默克密理愽
  • merck millipore,默克密理博,345733,Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

  • merck millipore,默克密理博,345733,Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

    产品名称：Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem
    产品型号：345733
    Contains mainly N-acetylneuraminic acid.

    merck millipore,默克密理博,345733,Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,345733,Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

    重要规格表

    经验配方
    C₆₄H₁₁₈N₂O₂₁ · NH₄
    描述
    概述 Contains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
    M.W. 1198.5 (based on stearoyl - 18:0).
    产品目录编号 345733
    品牌系列 Calbiochem®
    同义词 Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
    参考
    参考 Katoh, N. 1995. Life Sci. 56, 157.
    Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
    Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
    Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
    产品信息
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₆₄H₁₁₈N₂O₂₁ · NH₄
    化学配方 C₆₄H₁₁₈N₂O₂₁ · NH₄
    Molar Mass 1269.7
    可逆 N
    结构配方图像
    生物信息
    主靶 Protein kinase C, EGF-receptor tyrosine kinase
    主靶IC50 100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions
    纯度 ≥98% by TLC
    理化信息
    细胞可渗透 N
    溶解度 Chloroform:MeOH (2:1)
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,345733,Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

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